5. The Fantastic Four
The Fantastic Four haven’t had a great cinematic run. Some would argue they haven’t even had a good one. The Fantastic Four is, er was, one of the major teams in Marvel Comics, but they haven’t been together since the Secret Wars crossover event back in 2015. The Fantastic Four were a major influence in the Marvel universe between Reed Richards, a.k.a. Mister Fantastic, often being the go-to scientist in the comics. Also, Doctor Doom and the rest of their rogues alone are enough reason for them to have their own game.
The Fantastic Four would make for a great multiplayer action/adventure game, or even a single player game where players can choose a member and play through the story together, or switch between characters in single player. Characters like Black Panther, who was introduced in issue #52 of Fantastic Four, could make cameos and eventually be playable or just tag along as an AI ally in future games.